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1

Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective

Albuquerque, David, Stice, Eric, Rodríguez-López, Raquel, Manco, Licíno, Nóbrega, Clévio

Journal:

Molecular Genetics and Genomics

Year:

2015

Language:

english

File:

PDF, 720 KB

english, 2015

2

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Spinocerebellar Ataxia Type 17 (SCA17)

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 864 KB

english, 2018

3

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Clinical Features of Huntington’s Disease

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 538 KB

english, 2018

4

Overexpression of Mutant Ataxin-3 in Mouse Cerebellum Induces Ataxia and Cerebellar Neuropathology

Nóbrega, Clévio, Nascimento-Ferreira, Isabel, Onofre, Isabel, Albuquerque, David, Conceição, Mariana, Déglon, Nicole, Almeida, Luís Pereira

Journal:

Year:

2013

Language:

english

File:

PDF, 1.33 MB

english, 2013

5

Diagnosing Portuguese Students' Misconceptions about the Mineral Concept

Monteiro, António, Nóbrega, Clévio, Abrantes, Isabel, Gomes, Celeste

Journal:

International Journal of Science Education

Year:

2012

Language:

english

File:

PDF, 413 KB

english, 2012

6

Association study of common polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5 and OLFM4 genes with obesity-related traits among Portuguese children

Albuquerque, David, Nóbrega, Clévio, Rodríguez-López, Raquel, Manco, Licínio

Journal:

Journal of Human Genetics

Year:

2014

Language:

english

File:

PDF, 423 KB

english, 2014

7

The lactase persistence -13910C>T polymorphism shows indication of association with abdominal obesity among Portuguese children

Albuquerque, David, Nóbrega, Clévio, Manco, Licínio

Journal:

Acta Paediatrica

Year:

2013

Language:

english

File:

PDF, 110 KB

english, 2013

8

Molecular Mechanisms Underpinning the Development of Obesity ||

Nóbrega, Clévio, Rodriguez-López, Raquel

Year:

2014

Language:

english

File:

PDF, 4.71 MB

english, 2014

9

Molecular Mechanisms Underpinning the Development of Obesity || Genetic Contribution: Common Forms of Obesity

Nóbrega, Clévio, Rodriguez-López, Raquel

Year:

2014

Language:

english

File:

PDF, 997 KB

english, 2014

10

Neuropeptide Y stimulates autophagy in hypothalamic neurons

Aveleira, Célia A., Botelho, Mariana, Carmo-Silva, Sara, Pascoal, Jorge F., Ferreira-Marques, Marisa, Nóbrega, Clévio, Cortes, Luísa, Valero, Jorge, Sousa-Ferreira, Lígia, Álvaro, Ana R., Santana, Mag

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 2.23 MB

english, 2015

11

Molecular Mechanisms Underpinning the Development of Obesity || Epigenetics of Human Obesity: A Link Between Genetics and Nutrition

Nóbrega, Clévio, Rodriguez-López, Raquel

Year:

2014

Language:

english

File:

PDF, 1.35 MB

english, 2014

12

Molecular Mechanisms Underpinning the Development of Obesity || The Role of the GWAS Identified FTO Locus in Regulating Body Size and Composition

Nóbrega, Clévio, Rodriguez-López, Raquel

Year:

2014

Language:

english

File:

PDF, 1.16 MB

english, 2014

13

Massacre, Mardi Gras, and Torture in Early New Orleans

Albuquerque, David, Nóbrega, Clévio, Manco, Licínio, López, Miguel

Journal:

The William and Mary Quarterly

Year:

2013

Language:

english

File:

PDF, 22.13 MB

english, 2013

14

Association of FTO Polymorphisms with Obesity and Obesity-Related Outcomes in Portuguese Children

Albuquerque, David, Nóbrega, Clévio, Manco, Licínio, López, Miguel

Journal:

Year:

2013

Language:

english

File:

PDF, 150 KB

english, 2013

15

Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado–Joseph disease

Nóbrega, Clévio, Carmo-Silva, Sara, Albuquerque, David, Vasconcelos-Ferreira, Ana, Vijayakumar, Udaya-Geetha, Mendonça, Liliana, Hirai, Hirokazu, Pereira de Almeida, Luís

Journal:

Year:

2015

Language:

english

File:

PDF, 2.49 MB

english, 2015

16

Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype

Conceição, Mariana, Mendonça, Liliana, Nóbrega, Clévio, Gomes, Célia, Costa, Pedro, Hirai, Hirokazu, Moreira, João Nuno, Lima, Maria C., Manjunath, N., Pereira de Almeida, Luís

Journal:

Year:

2015

Language:

english

File:

PDF, 4.02 MB

english, 2015

17

Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles

Conceição, Mariana, Mendonça, Liliana, Nóbrega, Clévio, Gomes, Célia, Costa, Pedro, Hirai, Hirokazu, Moreira, João Nuno, Lima, Maria C., Manjunath, N., de Almeida, Luís Pereira

Journal:

Year:

2016

Language:

english

File:

PDF, 1.97 MB

english, 2016

18

Neuropeptide Y1 and Y5 receptors activation stimulate autophagic flux in mouse hypothalamic neurons

Botelho, Mariana, Aveleira, Célia A., Carmo-Silva, Sara, Pascoal, Jorge, Ferreira-Marques, Marisa, Nóbrega, Clévio, Cortes, Luísa, Valero, Jorge, Sousa-Ferreira, Lígia, Álvaro, Ana R., Santana, Magda,

Journal:

Year:

2016

Language:

english

File:

PDF, 51 KB

english, 2016

19

582. Role of MicroRNA Deregulation in Machado-Joseph Disease

Geetha Vijayakumar, Udaya, Carmona, Vítor, Nóbrega, Clévio, Ferreira, Lígia, Pereira de Almeida, Luís

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 476 KB

english, 2015

20

Unraveling the Role of Ataxin-2 in Metabolism

Carmo-Silva, Sara, Nobrega, Clevio, Pereira de Almeida, Luís, Cavadas, Claudia

Journal:

Trends in Endocrinology & Metabolism

Year:

2017

Language:

english

File:

PDF, 1.34 MB

english, 2017

21

The contribution of genetics and environment to obesity

Albuquerque, David, Nóbrega, Clévio, Manco, Licínio, Padez, Cristina

Journal:

British Medical Bulletin

Year:

2017

Language:

english

File:

PDF, 331 KB

english, 2017

22

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || The Neuropathology of Spinocerebellar Ataxia Type 3/Machado-Joseph Disease

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 1.10 MB

english, 2018

23

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Mitochondrial Dysfunction in Huntington’s Disease

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 545 KB

english, 2018

24

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Planning Future Clinical Trials for Machado-Joseph Disease

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 384 KB

english, 2018

25

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Towards the Identification of Molecular Biomarkers of Spinocerebellar Ataxia Type 3 (SCA3)/Machado-Joseph Disease (MJD)

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 233 KB

english, 2018

26

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Origins and Spread of Machado-Joseph Disease Ancestral Mutations Events

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 157 KB

english, 2018

27

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || RNA Related Pathology in Huntington’s Disease

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 196 KB

english, 2018

28

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Genetic Rodent Models of Huntington Disease

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 338 KB

english, 2018

29

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Stem Cell-Based Therapies for Polyglutamine Diseases

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 398 KB

english, 2018

30

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 389 KB

english, 2018

31

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Pharmacological Therapies for Machado-Joseph Disease

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 351 KB

english, 2018

32

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Animal Models of Machado-Joseph Disease

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 229 KB

english, 2018

33

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Polyglutamine-Independent Features in Ataxin-3 Aggregation and Pathogenesis of Machado-Joseph Disease

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 304 KB

english, 2018

34

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Molecular Mechanisms and Therapeutic Strategies in Spinocerebellar Ataxia Type 7

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 676 KB

english, 2018

35

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Spinocerebellar Ataxia Type 1: Molecular Mechanisms of Neurodegeneration and Preclinical Studies

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 312 KB

english, 2018

36

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Gene Therapies for Polyglutamine Diseases

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 616 KB

english, 2018

37

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Clinical Features of Machado-Joseph Disease

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 234 KB

english, 2018

38

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || X-Linked Spinal and Bulbar Muscular Atrophy: From Clinical Genetic Features and Molecular Pathology to Mechanisms Underlying Disease Toxicity

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 495 KB

english, 2018

39

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Spinocerebellar Ataxia Type 2

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 537 KB

english, 2018

40

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 || Spinocerebellum Ataxia Type 6: Molecular Mechanisms and Calcium Channel Genetics

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 466 KB

english, 2018

41

[Advances in Experimental Medicine and Biology] Polyglutamine Disorders Volume 1049 ||

Nóbrega, Clévio, Pereira de Almeida, Luís

Year:

2018

Language:

english

File:

PDF, 9.46 MB

english, 2018

42

Moderate Long-Term Modulation of Neuropeptide Y in Hypothalamic Arcuate Nucleus Induces Energy Balance Alterations in Adult Rats

Sousa-Ferreira, Lígia, Garrido, Manuel, Nascimento-Ferreira, Isabel, Nobrega, Clévio, Santos-Carvalho, Ana, Álvaro, Ana Rita, Rosmaninho-Salgado, Joana, Kaster, Manuella, Kügler, Sebastian, Pereira de

Journal:

Year:

2011

Language:

english

File:

PDF, 692 KB

english, 2011

43

Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice

Nóbrega, Clévio, Nascimento-Ferreira, Isabel, Onofre, Isabel, Albuquerque, David, Hirai, Hirokazu, Déglon, Nicole, de Almeida, Luís Pereira, Chiesa, Roberto

Journal:

Year:

2013

Language:

english

File:

PDF, 675 KB

english, 2013

44

Machado-Joseph disease / Spinocerebellar ataxia type 3:lessons from disease pathogenesis and clues into therapy

Matos, Carlos, Pereira de Almeida, Luís, Nóbrega, Clévio

Journal:

Journal of Neurochemistry

Year:

2018

Language:

english

File:

PDF, 891 KB

english, 2018

45

Motor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive Review

Alves-Cruzeiro, João M. Da Conceição, Mendonça, Liliana, Pereira de Almeida, Luís, Nóbrega, Clévio

Journal:

Frontiers in Neuroscience

Year:

2016

Language:

english

File:

PDF, 1.09 MB

english, 2016

46

Editorial: Gene Silencing and Editing Strategies for Neurodegenerative Diseases

Nóbrega, Clévio, Alves, Sandro

Journal:

Frontiers in Neuroscience

Year:

2018

Language:

english

File:

PDF, 161 KB

english, 2018

47

Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease

Oliveira Miranda, Catarina, Marcelo, Adriana, Silva, Teresa Pereira, Barata, João, Vasconcelos-Ferreira, Ana, Pereira, Dina, Nóbrega, Clévio, Duarte, Sónia, Barros, Inês, Alves, Joana, Sereno, José, P

Journal:

Molecular Therapy

Year:

2018

Language:

english

File:

PDF, 3.86 MB

english, 2018

48

Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado-Joseph disease models

Marcelo, Adriana, Brito, Filipa, Carmo-Silva, Sara, Matos, Carlos A, Alves-Cruzeiro, João, Vasconcelos-Ferreira, Ana, Koppenol, Rebekah, Mendonça, Liliana, Almeida, Luís Pereira, Nóbrega, Clévio

Journal:

Human Molecular Genetics

Year:

2018

Language:

english

File:

PDF, 796 KB

english, 2018

49

RNAi therapy for Machado-Joseph disease: long-term safety profile of lentiviral vectors encoding shRNAs targeting mutant ataxin-3

Nobrega, Clévio, Codesso, José M, Mendonça, Liliana, Pereira de Almeida, Luis

Journal:

Human Gene Therapy

Year:

2019

Language:

english

File:

PDF, 3.27 MB

english, 2019

50

Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models

Mendonça, Liliana S, Nóbrega, Clévio, Tavino, Silvia, Brinkhaus, Maximilian, Matos, Carlos, Tomé, Sandra, Moreira, Ricardo, Henriques, Daniel, Kaspar, Brian K, de Almeida, Luís Pereira

Journal:

Human Molecular Genetics

Year:

2019

Language:

english

File:

PDF, 3.67 MB

english, 2019